Congenital rubella is the infection of a foetus with rubella virus following the infection of the mother during pregnancy. Rubella is a mild febrile rash illness caused by rubella virus and is transmitted from person to person via droplets (the virus is present in throat. Congenital rubella refers to the group of birth defects that occur in an infant whose mother is infected with the virus that causes German measles (rubella) during. Fortunately, because of the successful immunization program initiated in the United States in , rubella infection and congenital rubella.


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Disease factsheet about congenital rubella syndrome (CRS)

Persistence of rubella-specific IgG in the congenital rubella after 6 to 12 mo suggests congenital infection. Detection of rubella-specific IgM antibodies generally also indicates rubella infection, but false-positive IgM results can occur. Specimens from the nasopharynx, urine, CSF, buffy coat, and conjunctiva congenital rubella infants with CRS usually contain virus; samples from the nasopharynx usually offer the best sensitivity for culture, and the laboratory should be notified that rubella virus is suspected.

In a few centers, diagnoses can be made prenatally by detecting the virus in amniotic fluid, detecting rubella-specific IgM in fetal blood, or applying RT-PCR techniques to fetal blood or chorionic villus biopsy specimens.

Other tests include congenital rubella CBC with differential, CSF analysis, and x-ray examination of the bones to detect characteristic radiolucencies. Thorough ophthalmologic and cardiac evaluations are also congenital rubella.


Treatment Possibly immune globulin for the mother No specific therapy is available for maternal or congenital rubella infection. Congenital rubella imported, import-linked, and imported-virus cases are considered collectively to be import-associated congenital rubella.

For national reporting, however, cases will be classified as either internationally imported or US-acquired.

WHO | Rubella and Congenital Rubella Syndrome (CRS)

Laboratory Testing Diagnostic tests used to confirm CRS include serologic assays and detection of rubella virus. Efforts should be made to obtain clinical specimens for virus isolation congenital rubella infants at the congenital rubella of the initial investigation see Appendix 15 [2 pages].


However, because infants with CRS may shed virus from the throat and urine for a prolonged period—sometimes up to a year or congenital rubella longer—specimens obtained later may also yield rubella virus. Why is congenital rubella syndrome a problem?

The rubivirus can be spread from congenital rubella pregnant mother to her fetus through the bloodstream. Babies born with congenital rubella syndrome may have severe birth defects.

Surveillance Manual | Congenital Rubella Syndrome | VPDs | Vaccines | CDC

congenital rubella What are the chances my baby will be born with congenital rubella syndrome? Transmission Rubella is a mild febrile rash illness caused by rubella virus and is transmitted from person to person via droplets the virus is present in throat congenital rubella.


It can affect anyone who is not protected. However, as many as 85 out of babies born to mothers who had rubella shortly before or during the first three months of pregnancy may develop health problems, so-called congenital rubella syndrome.

The type of complications may vary in nature and severity, depending on the stage of pregnancy when the infection congenital rubella. Complications affect 85 out of babies whose mothers had rubella just before or at the beginning of the pregnancy. Complications include deafness, cataracts, heart defects, brain disorders, mental retardation, bone alterations, liver and spleen damage.

Furthermore, an infant infected congenital rubella rubella during pregnancy can continue to shed the virus for about a year, sometimes longer.